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Small-scale production of 67Cu for a preclinical study via the 64Ni(α, p)67Cu channel
https://repo.qst.go.jp/records/48549
https://repo.qst.go.jp/records/48549a7444e32-eeda-49fe-a1df-5bbb515a471d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-28 | |||||
| タイトル | ||||||
| タイトル | Small-scale production of 67Cu for a preclinical study via the 64Ni(α, p)67Cu channel | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohya, Tomoyuki
× Ohya, Tomoyuki× Zhang, Ming-Rong× Nagatsu, Kotaro× Fukada, Masami× Hanyu, Masayuki× Suzuki, Hisashi× Minegishi, Katsuyuki× 大矢 智幸× 張 明栄× 永津 弘太郎× 深田 正美× 破入 正行× 鈴木 寿× 峯岸 克行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Introduction: Copper-67 is an attractive beta emitter for targeted radionuclide therapy. However, the availability of 67Cu limits its potential use in a wide range of applications. In this study, we propose an easy small-scale production of 67Cu using 64Ni target for a preclinical study. Methods: 67Cu was produced from an electrodeposited 64Ni target via the 64Ni(α, p)67Cu-reaction with a 36 MeV alpha beam at 15 eμA (electrical microampere) conducted for 7 h. The chemical separation process of 67Cu from the 64Ni target was performed following by our routine procedure of 64Cu production using cation exchange resin, AG50W-X8, with minor modification. The target and its holder were redesigned in the preparation. Results: The 67Cu product was obtained with a yield of 55 ± 10 MBq at the end of bombardment (EOB), and the yield was 527 ± 96 kBq/μAh at the EOB. The copper impurity in the product was low (0.71 ± 0.21 μg) and the product was suitable for a preclinical study. Conclusions: We produced 67Cu with sufficient activity and quality for a preclinical study using a 64Ni-target. This production method also showed advantages as a routine method, i.e., shorten the processing time, reducing the radiation exposure and ready target recycling, when compared with that of a conventional Zn-target used for 67Cu production. |
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| 書誌情報 |
Nuclear Medicine and Biology 巻 59, p. 56-60, 発行日 2018-04 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.nucmedbio.2018.01.002 | |||||
