@article{oai:repo.qst.go.jp:00048549,
 author = {Ohya, Tomoyuki and Zhang, Ming-Rong and Nagatsu, Kotaro and Fukada, Masami and Hanyu, Masayuki and Suzuki, Hisashi and Minegishi, Katsuyuki and 大矢 智幸 and 張 明栄 and 永津 弘太郎 and 深田 正美 and 破入 正行 and 鈴木 寿 and 峯岸 克行},
 journal = {Nuclear Medicine and Biology},
 month = {Apr},
 note = {Introduction: Copper-67 is an attractive beta emitter for targeted radionuclide therapy. However, the availability of 67Cu limits its potential use in a wide range of applications. In this study, we propose an easy small-scale production of 67Cu using 64Ni target for a preclinical study. 
Methods: 67Cu was produced from an electrodeposited 64Ni target via the 64Ni(α, p)67Cu-reaction with a 36 MeV alpha beam at 15 eμA (electrical microampere) conducted for 7 h. The chemical separation process of 67Cu from the 64Ni target was performed following by our routine procedure of 64Cu production using cation exchange resin, AG50W-X8, with minor modification. The target and its holder were redesigned in the preparation.
Results: The 67Cu product was obtained with a yield of 55 ± 10 MBq at the end of bombardment (EOB), and the yield was 527 ± 96 kBq/μAh at the EOB. The copper impurity in the product was low (0.71 ± 0.21 μg) and the product was suitable for a preclinical study.
Conclusions: We produced 67Cu with sufficient activity and quality for a preclinical study using a 64Ni-target. This production method also showed advantages as a routine method, i.e., shorten the processing time, reducing the radiation exposure and ready target recycling, when compared with that of a conventional Zn-target used for 67Cu production.},
 pages = {56--60},
 title = {Small-scale production of 67Cu for a preclinical study via the 64Ni(α, p)67Cu channel},
 volume = {59},
 year = {2018}
}