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Modification of nitroxyl contrast agents with multiple spins and their proton T1 relaxivity
https://repo.qst.go.jp/records/48492
https://repo.qst.go.jp/records/48492d19cc7dd-ab6a-47bb-b2f4-9135ded21a1a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-02-14 | |||||
| タイトル | ||||||
| タイトル | Modification of nitroxyl contrast agents with multiple spins and their proton T1 relaxivity | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Ken-ichiro
× Matsumoto, Ken-ichiro× Yakumaru, Haruko× Narazaki, Michiko× Nakagawa, Hidehiko× Anzai, Kazunori× Ikehira, Hiroo× Ikota, Nobuo× 松本 謙一郎× 薬丸 晴子× 楢崎 美智子× 安西 和紀× 池平 博夫× 伊古田 暢夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The purpose of this study is to test the performance of multi-spin nitroxyl contrast agents for improving the sensitivity of MR detection for nitroxyl contrast agents. The relation between T1 relaxivity and the number of paramagnetic centers in a molecule was investigated. Compound-1 is a single molecule of methoxycarbonyl-PROXYL (MC-PROXYL). Two and three MC-PROXYL molecules were chemically coupled to obtain compounds-2 and -3, which have two and three nitroxyl spins in the molecule. A good linear relation, the slope of which increased depending on the number of nitroxyl spins in the molecule, was obtained between T1-weighted (FLASH) MR image contrast enhancement at 7 T and the concentration of nitroxyl contrast agents. T1-weighted MR image contrast enhancement and T1-relaxivity levels of nitroxyl contrast agents were increased depending on the number of nitroxyl spins in the molecule. Multi-coupling nitroxyl molecules can enhance the T1-weighted contrast effect, while maintaining the quantitative behavior of the molecule for up to three spins. | |||||
| 書誌情報 |
Magnetic Resonance Imaging 巻 26, 号 1, p. 117-121, 発行日 2008-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0730-725X | |||||
