{"created":"2023-05-15T14:37:35.443174+00:00","id":48492,"links":{},"metadata":{"_buckets":{"deposit":"bae724fa-06d8-44d2-9913-35c5e3d3b93c"},"_deposit":{"created_by":1,"id":"48492","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48492"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048492","sets":["1"]},"author_link":["487512","487513","487515","487511","487514","487519","487509","487518","487516","487517","487520","487510","487508"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"121","bibliographicPageStart":"117","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Magnetic Resonance Imaging"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The purpose of this study is to test the performance of multi-spin nitroxyl contrast agents for improving the sensitivity of MR detection for nitroxyl contrast agents. The relation between T1 relaxivity and the number of paramagnetic centers in a molecule was investigated. Compound-1 is a single molecule of methoxycarbonyl-PROXYL (MC-PROXYL). Two and three MC-PROXYL molecules were chemically coupled to obtain compounds-2 and -3, which have two and three nitroxyl spins in the molecule. A good linear relation, the slope of which increased depending on the number of nitroxyl spins in the molecule, was obtained between T1-weighted (FLASH) MR image contrast enhancement at 7 T and the concentration of nitroxyl contrast agents. T1-weighted MR image contrast enhancement and T1-relaxivity levels of nitroxyl contrast agents were increased depending on the number of nitroxyl spins in the molecule. Multi-coupling nitroxyl molecules can enhance the T1-weighted contrast effect, while maintaining the quantitative behavior of the molecule for up to three spins.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0730-725X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Ken-ichiro"}],"nameIdentifiers":[{"nameIdentifier":"487508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yakumaru, Haruko"}],"nameIdentifiers":[{"nameIdentifier":"487509","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Narazaki, Michiko"}],"nameIdentifiers":[{"nameIdentifier":"487510","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakagawa, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"487511","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anzai, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"487512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikehira, Hiroo"}],"nameIdentifiers":[{"nameIdentifier":"487513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikota, Nobuo"}],"nameIdentifiers":[{"nameIdentifier":"487514","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"薬丸 晴子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"楢崎 美智子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安西 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池平 博夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487519","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊古田 暢夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"487520","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Modification of nitroxyl contrast agents with multiple spins and their proton T1 relaxivity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Modification of nitroxyl contrast agents with multiple spins and their proton T1 relaxivity"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-02-14"},"publish_date":"2018-02-14","publish_status":"0","recid":"48492","relation_version_is_last":true,"title":["Modification of nitroxyl contrast agents with multiple spins and their proton T1 relaxivity"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:27:28.731587+00:00"}