@article{oai:repo.qst.go.jp:00048492,
 author = {Matsumoto, Ken-ichiro and Yakumaru, Haruko and Narazaki, Michiko and Nakagawa, Hidehiko and Anzai, Kazunori and Ikehira, Hiroo and Ikota, Nobuo and 松本 謙一郎 and 薬丸 晴子 and 楢崎 美智子 and 安西 和紀 and 池平 博夫 and 伊古田 暢夫},
 issue = {1},
 journal = {Magnetic Resonance Imaging},
 month = {Jan},
 note = {The purpose of this study is to test the performance of multi-spin nitroxyl contrast agents for improving the sensitivity of MR detection for nitroxyl contrast agents. The relation between T1 relaxivity and the number of paramagnetic centers in a molecule was investigated. Compound-1 is a single molecule of methoxycarbonyl-PROXYL (MC-PROXYL). Two and three MC-PROXYL molecules were chemically coupled to obtain compounds-2 and -3, which have two and three nitroxyl spins in the molecule. A good linear relation, the slope of which increased depending on the number of nitroxyl spins in the molecule, was obtained between T1-weighted (FLASH) MR image contrast enhancement at 7 T and the concentration of nitroxyl contrast agents. T1-weighted MR image contrast enhancement and T1-relaxivity levels of nitroxyl contrast agents were increased depending on the number of nitroxyl spins in the molecule. Multi-coupling nitroxyl molecules can enhance the T1-weighted contrast effect, while maintaining the quantitative behavior of the molecule for up to three spins.},
 pages = {117--121},
 title = {Modification of nitroxyl contrast agents with multiple spins and their proton T1 relaxivity},
 volume = {26},
 year = {2008}
}