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Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam
https://repo.qst.go.jp/records/48487
https://repo.qst.go.jp/records/48487155a7072-dccf-4e28-9de8-6e057346f395
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-04-27 | |||||
| タイトル | ||||||
| タイトル | Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ken-ichiro, Matsumoto
× Ken-ichiro, Matsumoto× Nagata, Katsura× Yamamoto, Haruhiko× Endo, Kazutoyo× Anzai, Kazunori× Aoki, Ichio× Kenichiro, Matsumoto× Kazunori, Anzai× Ichio, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The detection of free radical reactions in a gelatin sample irradiated by heavy-ion beam was tested using electron paramagnetic resonance (EPR) spectroscopic and MRI methods. Geometry and the amount of free radical eneration in a sample are described. A reaction mixture containing glutathione and a nitroxyl radical, TEMPOL, was caked with gelatin, and then irradiated with a 290 MeV carbon beam. The amount of free radical generation in a solic sample was almost flat from the surface to the beam end, except for a small peak, the peak radioactivation profile, and then steeply decrased approaching the beam end. Total free radical reactions obtained with carbon-beam irradication were expected to be less than one-third of X-ray irradiation, when the same dose for a deeper target was considered. Both EPR and MRI are useful tools to visualize free radical generation in samples irradiated by a heavy-ion beam. The EPR-based method is more sensitive and quantitative than the MRI-based method; however, the MRI method can achieve high spatial resolution. This study gives the rationale for a redox regulation trial using antioxidant drugs to reduce the side effects on normal tissues in carbon-beam therapy. | |||||
| 書誌情報 |
Magnetic Resonance in Medicine 巻 61, 号 5, p. 1033-1039, 発行日 2009-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0740-3194 | |||||
