{"created":"2023-05-15T14:37:35.226071+00:00","id":48487,"links":{},"metadata":{"_buckets":{"deposit":"8f343486-63e1-4f12-8947-21a3db0a6814"},"_deposit":{"created_by":1,"id":"48487","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48487"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048487","sets":["1"]},"author_link":["1014262","1014266","1014267","1014265","1014264","1014268","1014263","1014261","1014269"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"1039","bibliographicPageStart":"1033","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Magnetic Resonance in Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The detection of free radical reactions in a gelatin sample irradiated by heavy-ion beam was tested using electron paramagnetic resonance (EPR) spectroscopic and MRI methods. Geometry and the amount of free radical eneration in a sample are described. A reaction mixture containing glutathione and a nitroxyl radical, TEMPOL, was caked with gelatin, and then irradiated with a 290 MeV carbon beam. The amount of free radical generation in a solic sample was almost flat from the surface to the beam end, except for a small peak, the peak radioactivation profile, and then steeply decrased approaching the beam end. Total free radical reactions obtained with carbon-beam irradication were expected to be less than one-third of X-ray irradiation, when the same dose for a deeper target was considered. Both EPR and MRI are useful tools to visualize free radical generation in samples irradiated by a heavy-ion beam. The EPR-based method is more sensitive and quantitative than the MRI-based method; however, the MRI method can achieve high spatial resolution. This study gives the rationale for a redox regulation trial using antioxidant drugs to reduce the side effects on normal tissues in carbon-beam therapy.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0740-3194","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ken-ichiro, Matsumoto"}],"nameIdentifiers":[{"nameIdentifier":"1014261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagata, Katsura"}],"nameIdentifiers":[{"nameIdentifier":"1014262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Haruhiko"}],"nameIdentifiers":[{"nameIdentifier":"1014263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endo, Kazutoyo"}],"nameIdentifiers":[{"nameIdentifier":"1014264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Anzai, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"1014265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"1014266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kenichiro, Matsumoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazunori, Anzai","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichio, Aoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1014269","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-27"},"publish_date":"2009-04-27","publish_status":"0","recid":"48487","relation_version_is_last":true,"title":["Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:49:12.439487+00:00"}