@article{oai:repo.qst.go.jp:00048487,
 author = {Ken-ichiro, Matsumoto and Nagata, Katsura and Yamamoto, Haruhiko and Endo, Kazutoyo and Anzai, Kazunori and Aoki, Ichio and Kenichiro, Matsumoto and Kazunori, Anzai and Ichio, Aoki},
 issue = {5},
 journal = {Magnetic Resonance in Medicine},
 month = {May},
 note = {The detection of free radical reactions in a gelatin sample irradiated by heavy-ion beam was tested using electron paramagnetic resonance (EPR) spectroscopic and MRI methods. Geometry and the amount of free radical eneration in a sample are described. A reaction mixture containing glutathione and a nitroxyl radical, TEMPOL, was caked with gelatin, and then irradiated with a 290 MeV carbon beam. The amount of free radical generation in a solic sample was almost flat from the surface to the beam end, except for a small peak, the peak radioactivation profile, and then steeply decrased approaching the beam end. Total free radical reactions obtained with carbon-beam irradication were expected to be less than one-third of X-ray irradiation, when the same dose for a deeper target was considered. Both EPR and MRI are useful tools to visualize free radical generation in samples irradiated by a heavy-ion beam. The EPR-based method is more sensitive and quantitative than the MRI-based method; however, the MRI method can achieve high spatial resolution. This study gives the rationale for a redox regulation trial using antioxidant drugs to reduce the side effects on normal tissues in carbon-beam therapy.},
 pages = {1033--1039},
 title = {Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam},
 volume = {61},
 year = {2009}
}