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A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation.
https://repo.qst.go.jp/records/48392
https://repo.qst.go.jp/records/4839248eb1c7c-ead5-4fc5-a6db-93389f974610
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-11-30 | |||||
タイトル | ||||||
タイトル | A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Wang, Lu
× Wang, Lu× Cheng, Ran× Fujinaga, Masayuki× Yang, Jian× Zhang, Yiding× Hatori, Akiko× Kumata, Katsushi× Yang, Jing× Vasdev, Neil× Du, Yunfei× Ran, Chongzhao× Zhang, Ming-Rong× Steven, H. Liang× 藤永 雅之× 張 一鼎× 羽鳥 晶子× 熊田 勝志× 張 明栄 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A suitable TSPO PET ligand may visualize and quantify neuroinflammation in a living brain. Herein we report a 18F-ligand, [18F]2 ([18F]FDPA), is radiolabeled in high yield and high specific activity based on our spirocyclic iodonium ylide (SCIDY) strategy. [18F]2 demonstrated saturable specific binding to TSPO, substantially elevated brain uptake, and slow washout of bound PET signal in the preclinical models of brain neuroinflammation (cerebral ischemia and Alzheimer's disease). | |||||
書誌情報 |
Journal of Medicinal Chemistry 巻 60, 号 12, p. 5222-5227, 発行日 2017-05 |
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出版者 | ||||||
出版者 | ELSEVIER | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0022-2623 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 28530834 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1021/acs.jmedchem.7b00432 |