{"created":"2023-05-15T14:37:31.015224+00:00","id":48392,"links":{},"metadata":{"_buckets":{"deposit":"e0a3302a-0838-44e5-be5f-fa31577d4df1"},"_deposit":{"created_by":1,"id":"48392","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48392"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048392","sets":["1"]},"author_link":["486431","486423","486427","486429","486434","486424","486428","486433","486420","486421","486422","486430","486436","486435","486432","486426","486425","486419"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"5227","bibliographicPageStart":"5222","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Journal of Medicinal Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A suitable TSPO PET ligand may visualize and quantify neuroinflammation in a living brain. Herein we report a 18F-ligand, [18F]2 ([18F]FDPA), is radiolabeled in high yield and high specific activity based on our spirocyclic iodonium ylide (SCIDY) strategy. [18F]2 demonstrated saturable specific binding to TSPO, substantially elevated brain uptake, and slow washout of bound PET signal in the preclinical models of brain neuroinflammation (cerebral ischemia and Alzheimer's disease).","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"ELSEVIER"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28530834","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.jmedchem.7b00432 ","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-2623","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wang, Lu"}],"nameIdentifiers":[{"nameIdentifier":"486419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Cheng, Ran"}],"nameIdentifiers":[{"nameIdentifier":"486420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"486421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yang, Jian"}],"nameIdentifiers":[{"nameIdentifier":"486422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding"}],"nameIdentifiers":[{"nameIdentifier":"486423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatori, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"486424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"486425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yang, Jing"}],"nameIdentifiers":[{"nameIdentifier":"486426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vasdev, Neil"}],"nameIdentifiers":[{"nameIdentifier":"486427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Du, Yunfei"}],"nameIdentifiers":[{"nameIdentifier":"486428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ran, Chongzhao"}],"nameIdentifiers":[{"nameIdentifier":"486429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"486430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Steven, H. Liang"}],"nameIdentifiers":[{"nameIdentifier":"486431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 一鼎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486433","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486435","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"486436","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-30"},"publish_date":"2017-11-30","publish_status":"0","recid":"48392","relation_version_is_last":true,"title":["A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:28:38.283682+00:00"}