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Overproduction of Reactive Oxygen Species - Obligatory or Not for Induction of Apoptosis by Anticancer Drugs
https://repo.qst.go.jp/records/48215
https://repo.qst.go.jp/records/482158f169079-158c-4736-92f5-a977ce2a531c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-07-26 | |||||
| タイトル | ||||||
| タイトル | Overproduction of Reactive Oxygen Species - Obligatory or Not for Induction of Apoptosis by Anticancer Drugs | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ivanova, Donika
× Ivanova, Donika× Zhelev, Zhivko× Aoki, Ichio× Bakalova, Rumiana× Higashi, Tatsuya× 青木 伊知男× バカロバ ルミアナ× 東 達也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species (ROS) and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS-independent pathways. We try to answer the question: "Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues?" The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress. | |||||
| 書誌情報 |
Chinese Journal of Cancer Research 巻 28, 号 4, p. 383-396, 発行日 2016-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1000-9604 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.21147/j.issn.1000-9604.2016.04.01 | |||||
