{"created":"2023-05-15T14:37:23.277831+00:00","id":48215,"links":{},"metadata":{"_buckets":{"deposit":"7fefd4e1-1f59-4daa-afac-006d1f67c96e"},"_deposit":{"created_by":1,"id":"48215","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48215"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048215","sets":["1"]},"author_link":["484409","484410","484408","484411","484406","484407","484413","484412"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"396","bibliographicPageStart":"383","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"Chinese Journal of Cancer Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species (ROS) and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS-independent pathways. We try to answer the question: \"Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues?\" The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress. ","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.21147/j.issn.1000-9604.2016.04.01","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1000-9604","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ivanova, Donika"}],"nameIdentifiers":[{"nameIdentifier":"484406","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhelev, Zhivko"}],"nameIdentifiers":[{"nameIdentifier":"484407","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"484408","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"484409","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"484410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"484411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"バカロバ ルミアナ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"484412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"484413","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Overproduction of Reactive Oxygen Species - Obligatory or Not for Induction of Apoptosis by Anticancer Drugs ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Overproduction of Reactive Oxygen Species - Obligatory or Not for Induction of Apoptosis by Anticancer Drugs "}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-26"},"publish_date":"2017-07-26","publish_status":"0","recid":"48215","relation_version_is_last":true,"title":["Overproduction of Reactive Oxygen Species - Obligatory or Not for Induction of Apoptosis by Anticancer Drugs "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:30:37.489764+00:00"}