@article{oai:repo.qst.go.jp:00048215,
 author = {Ivanova, Donika and Zhelev, Zhivko and Aoki, Ichio and Bakalova, Rumiana and Higashi, Tatsuya and 青木 伊知男 and バカロバ ルミアナ and 東 達也},
 issue = {4},
 journal = {Chinese Journal of Cancer Research},
 month = {Jun},
 note = {Many studies demonstrate that conventional anticancer drugs elevate intracellular level of reactive oxygen species (ROS) and alter redox-homeostasis of cancer cells. It is widely accepted that anticancer effect of these chemotherapeutics is due to induction of oxidative stress and ROS-mediated apoptosis in cancer. On the other hand, the harmful side effects of conventional anticancer chemotherapy are also due to increased production of ROS and disruption of redox-homeostasis of normal cells and tissues. This article describes the mechanisms for triggering and modulation of apoptosis through ROS-dependent and ROS-independent pathways. We try to answer the question: "Is it possible to induce highly specific apoptosis only in cancer cells, without overproduction of ROS, as well as without harmful effects on normal cells and tissues?" The review also suggests a new therapeutic strategy for selective killing of cancer cells, without significant impact on viability of normal cells and tissues, by combining anticancer drugs with redox-modulators, affecting specific signaling pathways and avoiding oxidative stress.},
 pages = {383--396},
 title = {Overproduction of Reactive Oxygen Species - Obligatory or Not for Induction of Apoptosis by Anticancer Drugs},
 volume = {28},
 year = {2016}
}