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Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study

https://repo.qst.go.jp/records/47797
https://repo.qst.go.jp/records/47797
e0214f6d-5011-4ce6-a682-d72d3758065b
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-04-26
タイトル
タイトル Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Shimada, Hitoshi

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WEKO 479800

Shimada, Hitoshi

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Kitamura, Soichiro

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WEKO 479801

Kitamura, Soichiro

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Shinoto, Hitoshi

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WEKO 479802

Shinoto, Hitoshi

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Endo, Hironobu

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WEKO 479803

Endo, Hironobu

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Niwa, Fumitoshi

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WEKO 479804

Niwa, Fumitoshi

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Hirano, Shigeki

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WEKO 479805

Hirano, Shigeki

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Zhang, Ming-Rong

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Zhang, Ming-Rong

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Suhara, Tetsuya

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WEKO 479807

Suhara, Tetsuya

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Higuchi, Makoto

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Higuchi, Makoto

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Kimura, Yasuyuki

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WEKO 479809

Kimura, Yasuyuki

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Kuwabara, Satoshi

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Kuwabara, Satoshi

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島田 斉

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en 島田 斉

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北村 聡一郎

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en 北村 聡一郎

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篠遠 仁

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en 篠遠 仁

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遠藤 浩信

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丹羽 文俊

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en 丹羽 文俊

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平野 成樹

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en 平野 成樹

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張 明栄

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須原 哲也

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樋口 真人

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木村 泰之

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抄録
内容記述タイプ Abstract
内容記述 INTRODUCTION:
Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear.
METHODS:
Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs).
RESULTS:
High tau burden was associated with aging and low-level education in PiB(-)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(-)-HC.
DISCUSSION:
The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.
書誌情報 Alzheimers Dement (Amst)

巻 6, p. 11-20, 発行日 2017-01
出版者
出版者 Elsevier
PubMed番号
識別子タイプ PMID
関連識別子 28138509
DOI
識別子タイプ DOI
関連識別子 10.1016/j.dadm.2016.12.009
関連サイト
識別子タイプ URI
関連識別子 http://www.sciencedirect.com/science/article/pii/S2352872916300720
関連名称 http://www.sciencedirect.com/science/article/pii/S2352872916300720
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