{"_buckets": {"deposit": "5b6d6420-478b-4ef5-a406-6a5aa1e490d4"}, "_deposit": {"created_by": 1, "id": "47797", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "47797"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00047797", "sets": ["1"]}, "author_link": ["479815", "479810", "479807", "479802", "479814", "479813", "479803", "479804", "479817", "479809", "479811", "479819", "479805", "479800", "479801", "479820", "479816", "479806", "479818", "479808", "479812"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-01", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "20", "bibliographicPageStart": "11", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "Alzheimers Dement (Amst)"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "INTRODUCTION:\nAmyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer\u0027s disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear.\nMETHODS:\nAssociations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs).\nRESULTS:\nHigh tau burden was associated with aging and low-level education in PiB(-)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(-)-HC.\nDISCUSSION:\nThe present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "28138509", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.dadm.2016.12.009", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.sciencedirect.com/science/article/pii/S2352872916300720"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.sciencedirect.com/science/article/pii/S2352872916300720", "subitem_relation_type_select": "URI"}}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shimada, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "479800", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kitamura, Soichiro"}], "nameIdentifiers": [{"nameIdentifier": "479801", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shinoto, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "479802", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Endo, Hironobu"}], "nameIdentifiers": [{"nameIdentifier": "479803", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Niwa, Fumitoshi"}], "nameIdentifiers": [{"nameIdentifier": "479804", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirano, Shigeki"}], "nameIdentifiers": [{"nameIdentifier": "479805", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong"}], "nameIdentifiers": [{"nameIdentifier": "479806", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suhara, Tetsuya"}], "nameIdentifiers": [{"nameIdentifier": "479807", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "479808", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yasuyuki"}], "nameIdentifiers": [{"nameIdentifier": "479809", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuwabara, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "479810", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "島田 斉", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479811", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "北村 聡一郎", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479812", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "篠遠 仁", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479813", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "遠藤 浩信", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479814", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "丹羽 文俊", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479815", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平野 成樹", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479816", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "張 明栄", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479817", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "須原 哲也", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479818", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "樋口 真人", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479819", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "木村 泰之", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "479820", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/47797", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-04-26"}, "publish_date": "2017-04-26", "publish_status": "0", "recid": "47797", "relation": {}, "relation_version_is_last": true, "title": ["Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study"], "weko_shared_id": -1}