{"created":"2023-05-15T14:37:05.079620+00:00","id":47797,"links":{},"metadata":{"_buckets":{"deposit":"5b6d6420-478b-4ef5-a406-6a5aa1e490d4"},"_deposit":{"created_by":1,"id":"47797","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47797"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047797","sets":["1"]},"author_link":["479815","479810","479807","479802","479814","479813","479803","479804","479817","479809","479811","479819","479805","479800","479801","479820","479816","479806","479818","479808","479812"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"20","bibliographicPageStart":"11","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Alzheimers Dement (Amst)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"INTRODUCTION:\nAmyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear.\nMETHODS:\nAssociations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs).\nRESULTS:\nHigh tau burden was associated with aging and low-level education in PiB(-)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(-)-HC.\nDISCUSSION:\nThe present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28138509","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.dadm.2016.12.009","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.sciencedirect.com/science/article/pii/S2352872916300720"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencedirect.com/science/article/pii/S2352872916300720","subitem_relation_type_select":"URI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata 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Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"479805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"479806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"479807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"479808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"479809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuwabara, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"479810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 斉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北村 聡一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤 浩信","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丹羽 文俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479820","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-04-26"},"publish_date":"2017-04-26","publish_status":"0","recid":"47797","relation_version_is_last":true,"title":["Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:35:27.440877+00:00"}