@article{oai:repo.qst.go.jp:00047797,
 author = {Shimada, Hitoshi and Kitamura, Soichiro and Shinoto, Hitoshi and Endo, Hironobu and Niwa, Fumitoshi and Hirano, Shigeki and Zhang, Ming-Rong and Suhara, Tetsuya and Higuchi, Makoto and Kimura, Yasuyuki and Kuwabara, Satoshi and 島田 斉 and 北村 聡一郎 and 篠遠 仁 and 遠藤 浩信 and 丹羽 文俊 and 平野 成樹 and 張 明栄 and 須原 哲也 and 樋口 真人 and 木村 泰之},
 journal = {Alzheimers Dement (Amst)},
 month = {Jan},
 note = {INTRODUCTION:
Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear.
METHODS:
Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [11C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [11C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs).
RESULTS:
High tau burden was associated with aging and low-level education in PiB(-)-HC and AD-spectrum groups, and with high Aβ burden and low-level education in all subjects. It was not Aβ but tau accumulation that showed significant associations with cognitive performance even in PiB(-)-HC.
DISCUSSION:
The present study indicated aging and low-level education after Aβ would be enhancers for tau pathology, associated with neurodegeneration and cognitive impairment in healthy and diseased elderly individuals.},
 pages = {11--20},
 title = {Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study},
 volume = {6},
 year = {2017}
}