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An improved 62Zn/62Cu generator based on a cation exchanger and its fully remote-controlled preparation for clinical use
https://repo.qst.go.jp/records/47690
https://repo.qst.go.jp/records/4769015fd6953-329f-445b-8613-1fe70f4b7f2d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-27 | |||||
| タイトル | ||||||
| タイトル | An improved 62Zn/62Cu generator based on a cation exchanger and its fully remote-controlled preparation for clinical use | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukumura, Toshimitsu
× Fukumura, Toshimitsu× Okada, Kazuhiro× Suzuki, Hisashi× Nakao, Ryuji× Mukai, Kensaku× Ferenc, Szelecsenyi× Kovacs, Zoltan× Suzuki, Kazutoshi× 福村 利光× 鈴木 寿× 中尾 隆士× 向井 健作× Ｆｅｒｅｎｃ Ｓｚｅｌｅｃｓｅｎｙｉ× ゾルタン コバックス× 鈴木 和年 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | OBJECTIVE: \nThe goal of this study was to develop an improved (62)Zn/(62)Cu generator based on cation exchange resin and remote preparation at high radioactivity scale for clinical use. METHODS: \nA natural Cu target was irradiated with proton beam in the energy range of 30-->19 MeV at a beam current of 10 muA for 1 h to obtain around 1.7 GBq of (62)Zn. The (62)Zn was isolated from the Cu target on an anion exchange column with more than 97% yield within 2.5 h from the EOB. The (62)Zn/(62)Cu generator was prepared by loading the (62)Zn(2+) on a Sep-Pak plus CM cartridge. RESULTS: \nThe generator showed high elution efficiency ( approximately 96%) using a small volume (ca. 3 ml) of a 200-mM glycine solution with a very low breakthrough of (62)Zn (<0.1%). CONCLUSIONS: \nThis (62)Zn/(62)Cu generator has been proven to be highly useful as a source of (62)Cu for the synthesis of (62)Cu-labeled compounds. The clinical application of [(62)Cu]Cu-ATSM produced with this generator has been already approved by the Institutional Review Board at the National Institute of Radiological Sciences. |
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| 書誌情報 |
Nuclear Medicine and Biology 巻 33, 号 6, p. 821-827, 発行日 2006-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
