@article{oai:repo.qst.go.jp:00047690,
 author = {Fukumura, Toshimitsu and Okada, Kazuhiro and Suzuki, Hisashi and Nakao, Ryuji and Mukai, Kensaku and Ferenc, Szelecsenyi and Kovacs, Zoltan and Suzuki, Kazutoshi and 福村 利光 and 鈴木 寿 and 中尾 隆士 and 向井 健作 and Ｆｅｒｅｎｃ Ｓｚｅｌｅｃｓｅｎｙｉ and ゾルタン コバックス and 鈴木 和年},
 issue = {6},
 journal = {Nuclear Medicine and Biology},
 month = {Aug},
 note = {OBJECTIVE:
\nThe goal of this study was to develop an improved (62)Zn/(62)Cu generator based on cation exchange resin and remote preparation at high radioactivity scale for clinical use.
METHODS:
\nA natural Cu target was irradiated with proton beam in the energy range of 30-->19 MeV at a beam current of 10 muA for 1 h to obtain around 1.7 GBq of (62)Zn. The (62)Zn was isolated from the Cu target on an anion exchange column with more than 97% yield within 2.5 h from the EOB. The (62)Zn/(62)Cu generator was prepared by loading the (62)Zn(2+) on a Sep-Pak plus CM cartridge.
RESULTS:
\nThe generator showed high elution efficiency ( approximately 96%) using a small volume (ca. 3 ml) of a 200-mM glycine solution with a very low breakthrough of (62)Zn (<0.1%).
CONCLUSIONS:
\nThis (62)Zn/(62)Cu generator has been proven to be highly useful as a source of (62)Cu for the synthesis of (62)Cu-labeled compounds. The clinical application of [(62)Cu]Cu-ATSM produced with this generator has been already approved by the Institutional Review Board at the National Institute of Radiological Sciences.},
 pages = {821--827},
 title = {An improved 62Zn/62Cu generator based on a cation exchanger and its fully remote-controlled preparation for clinical use},
 volume = {33},
 year = {2006}
}