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Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients
https://repo.qst.go.jp/records/47662
https://repo.qst.go.jp/records/476624c4659f0-e513-4b42-ada3-891eeb19f057
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-03-15 | |||||
| タイトル | ||||||
| タイトル | Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Michikawa, Yuichi
× Michikawa, Yuichi× Suga, Tomo× Ishikawa, Atsuko× Hayashi, Hideki× Oka, Akira× Inoko, Hidetoshi× Iwakawa, Mayumi× Imai, Takashi× 道川 祐市× 菅 智× 石川 敦子× 岩川 眞由美× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background The response of normal tissues in cancer patients undergoing radiotherapy varies, possibly due to genetic differences underlying variation in radiosensitivity. \nMethods Cancer patients (n = 360) were selected retrospectively from the RadGenomics project. Adverse effects within 3 months of radiotherapy completion were graded using the National Cancer Institute Common Toxicity Criteria; high grade group were grade 3 or more (n = 180), low grade group were grade 1 or less (n = 180). Pooled genomic DNA (gDNA) (n = 90 from each group) was screened using 23,244 microsatellites. Markers with different inter-group frequencies (Fisher exact test P < 0.05) were analyzed using the remaining pooled gDNA. Silencing RNA treatment was performed in cultured normal human skin fibroblasts. \nResults Forty-seven markers had positive association values; including one in the SEMA3A promoter region (P = 1.24 x10-5). SEMA3A knockdown enhanced radiation resistance. \nConclusions This study identified 47 putative radiosensitivity markers, and suggested a role for SEMA3A in radiosensitivity. |
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| 書誌情報 |
BMC Medical Genetics (Online Only URL:http://www.biomedcentral.com/bmcmedgenet) 巻 11, 号 123, p. 123-1-123-11, 発行日 2010-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1471-2350 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/1471-2350-11-123 | |||||
