{"created":"2023-05-15T14:36:59.126067+00:00","id":47662,"links":{},"metadata":{"_buckets":{"deposit":"b03a7674-ea8f-4435-998e-51ab9649a870"},"_deposit":{"created_by":1,"id":"47662","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47662"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047662","sets":["1"]},"author_link":["478115","478120","478114","478116","478118","478123","478117","478112","478122","478124","478119","478113","478121"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"123","bibliographicPageEnd":"123-11","bibliographicPageStart":"123-1","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"BMC Medical Genetics (Online Only URL:http://www.biomedcentral.com/bmcmedgenet)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nThe response of normal tissues in cancer patients undergoing radiotherapy varies, possibly due to genetic differences underlying variation in radiosensitivity.\n\\nMethods\nCancer patients (n = 360) were selected retrospectively from the RadGenomics project. Adverse effects within 3 months of radiotherapy completion were graded using the National Cancer Institute Common Toxicity Criteria; high grade group were grade 3 or more (n = 180), low grade group were grade 1 or less (n = 180). Pooled genomic DNA (gDNA) (n = 90 from each group) was screened using 23,244 microsatellites. Markers with different inter-group frequencies (Fisher exact test P < 0.05) were analyzed using the remaining pooled gDNA. Silencing RNA treatment was performed in cultured normal human skin fibroblasts.\n\\nResults\nForty-seven markers had positive association values; including one in the SEMA3A promoter region (P = 1.24 x10-5). SEMA3A knockdown enhanced radiation resistance.\n\\nConclusions\nThis study identified 47 putative radiosensitivity markers, and suggested a role for SEMA3A in radiosensitivity.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/1471-2350-11-123","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1471-2350","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Michikawa, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"478112","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suga, Tomo"}],"nameIdentifiers":[{"nameIdentifier":"478113","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"478114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"478115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oka, Akira"}],"nameIdentifiers":[{"nameIdentifier":"478116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoko, Hidetoshi"}],"nameIdentifiers":[{"nameIdentifier":"478117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"478118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"478119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"道川 祐市","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅 智","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 敦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478124","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-03-15"},"publish_date":"2017-03-15","publish_status":"0","recid":"47662","relation_version_is_last":true,"title":["Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:37:00.659687+00:00"}