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Brain Contrasting Ability of Blood-Brain-Barrier-Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging
https://repo.qst.go.jp/records/47632
https://repo.qst.go.jp/records/47632e9fa558f-91fb-43bc-be9e-a49600ab66d9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-02-02 | |||||
| タイトル | ||||||
| タイトル | Brain Contrasting Ability of Blood-Brain-Barrier-Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Ken-ichiro
× Matsumoto, Ken-ichiro× Yamasaki, Toshihide× Nakamura, Mizuki× Ishikawa, Junji× Ueno, Megumi× Nakanishi, Ikuo× Sekita, Aiko× Ozawa, Yoshikazu× Kamada, Tadashi× Aoki, Ichio× Yamada, Ken-ichi× 松本 謙一郎× 山崎 俊栄× 中村 美月× 上野 恵美× 中西 郁夫× 関田 愛子× 尾澤 芳和× 鎌田 正× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The detailed in vivo contrasting abilities of nitroxyl contrast agents in mouse brain were compared using T1-weighted MRI. Five types of five-membered-ring nitroxyl radical compound, which have been used as redox responsive contrast agents in several magnetic resonance-based imaging modalities, were tested. The blood-brain-barrier (BBB)-impermeable 3-carboxy-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CxP) could not be distributed in the brain. The slightly lipophilic 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CmP) showed slight distribution only in the ventricle, but not in the medulla and cortex. The amphiphilic 3-methoxy-carbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (MCP) had good initial uniform distribution in the brain and showed typical 2-phase signal decay profiles. A brain-seeking nitroxyl probe, acetoxymethyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl-3-carboxylate (CxP-AM), showed an accumulating phase, and then its accumulation was maintained in the medulla and ventricle regions, but not in the cortex. The lipophilic 4-(N-methyl piperidine)-2,2,5,5-tetramethylpyrroline-N-oxyl (23c) was well distributed in the cortex and medulla, but slightly in the ventricle, and showed relatively rapid linear signal decay. Nitroxyl contrast agents equipped with a suitable lipophilic substitution group could be BBB-permeable functional contrast agents. MR redox imaging, which can estimate not only the redox characteristics but also the detailed distribution of the contrast agents, is a good candidate for a theranostic tool. | |||||
| 書誌情報 |
Magnetic Resonance in Medicine 巻 76, 号 3, p. 935-945, 発行日 2016-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0740-3194 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/mrm.25918 | |||||
