{"created":"2023-05-15T14:36:57.779558+00:00","id":47632,"links":{},"metadata":{"_buckets":{"deposit":"4efc2fde-1574-4da8-92c5-4e773ad93e38"},"_deposit":{"created_by":1,"id":"47632","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47632"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047632","sets":["1"]},"author_link":["477638","477644","477628","477630","477635","477641","477646","477631","477629","477627","477633","477634","477637","477636","477632","477640","477642","477643","477639","477645"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"945","bibliographicPageStart":"935","bibliographicVolumeNumber":"76","bibliographic_titles":[{"bibliographic_title":"Magnetic Resonance in Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The detailed in vivo contrasting abilities of nitroxyl contrast agents in mouse brain were compared using T1-weighted MRI. Five types of five-membered-ring nitroxyl radical compound, which have been used as redox responsive contrast agents in several magnetic resonance-based imaging modalities, were tested. The blood-brain-barrier (BBB)-impermeable 3-carboxy-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CxP) could not be distributed in the brain. The slightly lipophilic 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CmP) showed slight distribution only in the ventricle, but not in the medulla and cortex. The amphiphilic 3-methoxy-carbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (MCP) had good initial uniform distribution in the brain and showed typical 2-phase signal decay profiles. A brain-seeking nitroxyl probe, acetoxymethyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl-3-carboxylate (CxP-AM), showed an accumulating phase, and then its accumulation was maintained in the medulla and ventricle regions, but not in the cortex. The lipophilic 4-(N-methyl piperidine)-2,2,5,5-tetramethylpyrroline-N-oxyl (23c) was well distributed in the cortex and medulla, but slightly in the ventricle, and showed relatively rapid linear signal decay. Nitroxyl contrast agents equipped with a suitable lipophilic substitution group could be BBB-permeable functional contrast agents. MR redox imaging, which can estimate not only the redox characteristics but also the detailed distribution of the contrast agents, is a good candidate for a theranostic tool.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/mrm.25918","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0740-3194","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsumoto, Ken-ichiro"}],"nameIdentifiers":[{"nameIdentifier":"477627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Toshihide"}],"nameIdentifiers":[{"nameIdentifier":"477628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Mizuki"}],"nameIdentifiers":[{"nameIdentifier":"477629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Junji"}],"nameIdentifiers":[{"nameIdentifier":"477630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ueno, Megumi"}],"nameIdentifiers":[{"nameIdentifier":"477631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"477632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sekita, Aiko"}],"nameIdentifiers":[{"nameIdentifier":"477633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ozawa, Yoshikazu"}],"nameIdentifiers":[{"nameIdentifier":"477634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"477635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"477636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Ken-ichi"}],"nameIdentifiers":[{"nameIdentifier":"477637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 俊栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 美月","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 恵美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関田 愛子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尾澤 芳和","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477646","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Brain Contrasting Ability of Blood-Brain-Barrier-Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Brain Contrasting Ability of Blood-Brain-Barrier-Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-02"},"publish_date":"2017-02-02","publish_status":"0","recid":"47632","relation_version_is_last":true,"title":["Brain Contrasting Ability of Blood-Brain-Barrier-Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:37:22.679713+00:00"}