@article{oai:repo.qst.go.jp:00047632,
 author = {Matsumoto, Ken-ichiro and Yamasaki, Toshihide and Nakamura, Mizuki and Ishikawa, Junji and Ueno, Megumi and Nakanishi, Ikuo and Sekita, Aiko and Ozawa, Yoshikazu and Kamada, Tadashi and Aoki, Ichio and Yamada, Ken-ichi and 松本 謙一郎 and 山崎 俊栄 and 中村 美月 and 上野 恵美 and 中西 郁夫 and 関田 愛子 and 尾澤 芳和 and 鎌田 正 and 青木 伊知男},
 issue = {3},
 journal = {Magnetic Resonance in Medicine},
 month = {Aug},
 note = {The detailed in vivo contrasting abilities of nitroxyl contrast agents in mouse brain were compared using T1-weighted MRI. Five types of five-membered-ring nitroxyl radical compound, which have been used as redox responsive contrast agents in several magnetic resonance-based imaging modalities, were tested. The blood-brain-barrier (BBB)-impermeable 3-carboxy-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CxP) could not be distributed in the brain. The slightly lipophilic 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-N-oxyl (CmP) showed slight distribution only in the ventricle, but not in the medulla and cortex. The amphiphilic 3-methoxy-carbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (MCP) had good initial uniform distribution in the brain and showed typical 2-phase signal decay profiles. A brain-seeking nitroxyl probe, acetoxymethyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl-3-carboxylate (CxP-AM), showed an accumulating phase, and then its accumulation was maintained in the medulla and ventricle regions, but not in the cortex. The lipophilic 4-(N-methyl piperidine)-2,2,5,5-tetramethylpyrroline-N-oxyl (23c) was well distributed in the cortex and medulla, but slightly in the ventricle, and showed relatively rapid linear signal decay. Nitroxyl contrast agents equipped with a suitable lipophilic substitution group could be BBB-permeable functional contrast agents. MR redox imaging, which can estimate not only the redox characteristics but also the detailed distribution of the contrast agents, is a good candidate for a theranostic tool.},
 pages = {935--945},
 title = {Brain Contrasting Ability of Blood-Brain-Barrier-Permeable Nitroxyl Contrast Agents for Magnetic Resonance RedOx Imaging},
 volume = {76},
 year = {2016}
}