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VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation.
https://repo.qst.go.jp/records/47499
https://repo.qst.go.jp/records/47499600c586a-4b08-4a12-b9bb-20d5304f4472
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-24 | |||||
| タイトル | ||||||
| タイトル | VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujisawa, Hiroshi
× Fujisawa, Hiroshi× Izumi, Nakajima Nakako× Sunada, Shigeaki× Lee, Younghyun× Hirakawa, Hirokazu× Yajima, Hirohiko× Fujimori, Akira× Uesaka, Mitsuru× Okayasu, Ryuichi× 藤澤 寛× 中島 菜花子× 砂田 成章× Ｌｅｅ Ｙｏｕｎｇｈｙｕｎ× 平川 博一× 矢島 浩彦× 藤森 亮× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The reason why high LET radiation accomplishes greater tumor-killing than X-rays is still not completely understood. One factor would be the clustered or complex-type DNA damages. We previously reported that complex DNA double-strand breaks produced by high LET radiation enhanced DNA end resection, and this could lead to higher kinase activity of ATR protein recruited to RPA-coated single-stranded DNA. Although the effect of ATR inhibition on cells exposed to low LET gamma-rays has recently been reported, little is known regarding the effect of ATR inhibitor on cells treated with high LET radiation. The purpose of this study is to investigate the effects of the ATR inhibitor VE-821 in human tumor and normal cells irradiated with high LET carbon ions. | |||||
| 書誌情報 |
Radiation Oncology (Online only URL:http://www.ro-journal.com/) 巻 10, p. 175, 発行日 2015-01 |
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| 出版者 | ||||||
| 出版者 | BioMed Central | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1748-717X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 26286029 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/s13014-015-0464-y | |||||
