{"created":"2023-05-15T14:36:51.924706+00:00","id":47499,"links":{},"metadata":{"_buckets":{"deposit":"eaec48d4-2e03-4c73-a6c3-2da063cf0e69"},"_deposit":{"created_by":1,"id":"47499","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47499"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047499","sets":["1"]},"author_link":["475934","475944","475941","475929","475931","475938","475935","475942","475933","475939","475940","475937","475943","475936","475932","475930","475928"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-01","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"175","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Radiation Oncology (Online only URL:http://www.ro-journal.com/)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The reason why high LET radiation accomplishes greater tumor-killing than X-rays is still not completely understood. One factor would be the clustered or complex-type DNA damages. We previously reported that complex DNA double-strand breaks produced by high LET radiation enhanced DNA end resection, and this could lead to higher kinase activity of ATR protein recruited to RPA-coated single-stranded DNA. Although the effect of ATR inhibition on cells exposed to low LET gamma-rays has recently been reported, little is known regarding the effect of ATR inhibitor on cells treated with high LET radiation. The purpose of this study is to investigate the effects of the ATR inhibitor VE-821 in human tumor and normal cells irradiated with high LET carbon ions.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26286029","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s13014-015-0464-y","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1748-717X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujisawa, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"475928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Izumi, Nakajima Nakako"}],"nameIdentifiers":[{"nameIdentifier":"475929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sunada, Shigeaki"}],"nameIdentifiers":[{"nameIdentifier":"475930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lee, Younghyun"}],"nameIdentifiers":[{"nameIdentifier":"475931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirakawa, Hirokazu"}],"nameIdentifiers":[{"nameIdentifier":"475932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yajima, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"475933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimori, Akira"}],"nameIdentifiers":[{"nameIdentifier":"475934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uesaka, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"475935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"475936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤澤 寛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 菜花子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"砂田 成章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｌｅｅ Ｙｏｕｎｇｈｙｕｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平川 博一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"矢島 浩彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森 亮","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475944","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-24"},"publish_date":"2016-08-24","publish_status":"0","recid":"47499","relation_version_is_last":true,"title":["VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:39:05.098056+00:00"}