@article{oai:repo.qst.go.jp:00047499,
 author = {Fujisawa, Hiroshi and Izumi, Nakajima Nakako and Sunada, Shigeaki and Lee, Younghyun and Hirakawa, Hirokazu and Yajima, Hirohiko and Fujimori, Akira and Uesaka, Mitsuru and Okayasu, Ryuichi and 藤澤 寛 and 中島 菜花子 and 砂田 成章 and Ｌｅｅ Ｙｏｕｎｇｈｙｕｎ and 平川 博一 and 矢島 浩彦 and 藤森 亮 and 岡安 隆一},
 journal = {Radiation Oncology (Online only URL:http://www.ro-journal.com/)},
 month = {Jan},
 note = {High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The reason why high LET radiation accomplishes greater tumor-killing than X-rays is still not completely understood. One factor would be the clustered or complex-type DNA damages. We previously reported that complex DNA double-strand breaks produced by high LET radiation enhanced DNA end resection, and this could lead to higher kinase activity of ATR protein recruited to RPA-coated single-stranded DNA. Although the effect of ATR inhibition on cells exposed to low LET gamma-rays has recently been reported, little is known regarding the effect of ATR inhibitor on cells treated with high LET radiation. The purpose of this study is to investigate the effects of the ATR inhibitor VE-821 in human tumor and normal cells irradiated with high LET carbon ions.},
 title = {VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation.},
 volume = {10},
 year = {2015}
}