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Thermoactivatable Polymer-grafted Liposomes for Low-invasive Image-guided Chemotherapy
https://repo.qst.go.jp/records/47459
https://repo.qst.go.jp/records/47459ecb699b3-38a3-4de4-8721-8cbe62d12585
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-08-10 | |||||
| タイトル | ||||||
| タイトル | Thermoactivatable Polymer-grafted Liposomes for Low-invasive Image-guided Chemotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Aoki, Ichio
× Aoki, Ichio× Yoneyama, Misao× Hirose, Jun× Minemoto, Yuzuru× Koyama, Takayoshi× Kokuryo, Daisuke× Murayama, Shuhei× Bakalova, Rumiana× Saga, Tusneo× Aoshima, Sadahito× Kono, Kenji× Ishizaka, Yukihito× 青木 伊知男× 米山 操× 國領 大介× 村山 周平× バカロバ ルミアナ× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The objective of this study was to develop a thermo-triggered, polymer-based liposomal drug carrier with an activatable MRI contrast property for monitoring the release of substances and for localized tumor therapy. The multimodal thermo-activatable polymer-grafted liposomes (MTPLs) was tested whether the accumulation of MTPLs in colon-26 grafted tumors could be visualized in vivo using MRI and optical imaging, whether MTPLs induce signal enhancement reflecting contents-release after triggering by tolerable short-term heating (42.5°C for 10 min) 8 h after MTPL administration (late-phase triggering), and whether MTPLs can provide a sufficient anti-tumor effect. The imaging and therapeutic properties of MTPLs were tested both in vitro and in vivo (BALB/c nude mice: heated group with MTPLs (n = 5), non-heated group with MTPLs (n = 5), heated group with doxorubicin-free MTPLs (n = 5), non-heated group with manganese-free MTPLs (n = 5), and kinetics observation group (n = 3); N = 23). Through in vivo MRI and fluorescent imaging, the MTPLs were shown to have significantly accumulated in the grafted colon-26 tumors 8 h after administration. Delayed thermo-triggering (9 h after administration) caused MR signal enhancement reflecting the contents-release upon short exposure to tolerable heat. In addition, significant anti-tumor effects were observed after treatment. The proposed polymer-based activatable MTPLs with a ‘delayed thermo-trigger’ provide a promising technology for cancer theranostics that allows for minimal side effects and rapid interactive therapy. | |||||
| 書誌情報 |
Translational Research 巻 166, 号 6, p. 660-673, 発行日 2015-08 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1878-1810 | |||||
