{"created":"2023-05-15T14:36:50.165556+00:00","id":47459,"links":{},"metadata":{"_buckets":{"deposit":"883df24b-2412-4c45-a4d8-33dade147deb"},"_deposit":{"created_by":1,"id":"47459","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47459"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047459","sets":["1"]},"author_link":["475441","475435","475432","475442","475443","475438","475444","475439","475437","475445","475436","475434","475430","475440","475429","475446","475433","475431"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"673","bibliographicPageStart":"660","bibliographicVolumeNumber":"166","bibliographic_titles":[{"bibliographic_title":"Translational Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The objective of this study was to develop a thermo-triggered, polymer-based liposomal drug carrier with an activatable MRI contrast property for monitoring the release of substances and for localized tumor therapy. The multimodal thermo-activatable polymer-grafted liposomes (MTPLs) was tested whether the accumulation of MTPLs in colon-26 grafted tumors could be visualized in vivo using MRI and optical imaging, whether MTPLs induce signal enhancement reflecting contents-release after triggering by tolerable short-term heating (42.5°C for 10 min) 8 h after MTPL administration (late-phase triggering), and whether MTPLs can provide a sufficient anti-tumor effect. The imaging and therapeutic properties of MTPLs were tested both in vitro and in vivo (BALB/c nude mice: heated group with MTPLs (n = 5), non-heated group with MTPLs (n = 5), heated group with doxorubicin-free MTPLs (n = 5), non-heated group with manganese-free MTPLs (n = 5), and kinetics observation group (n = 3); N = 23). Through in vivo MRI and fluorescent imaging, the MTPLs were shown to have significantly accumulated in the grafted colon-26 tumors 8 h after administration. Delayed thermo-triggering (9 h after administration) caused MR signal enhancement reflecting the contents-release upon short exposure to tolerable heat. In addition, significant anti-tumor effects were observed after treatment. The proposed polymer-based activatable MTPLs with a ‘delayed thermo-trigger’ provide a promising technology for cancer theranostics that allows for minimal side effects and rapid interactive therapy.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1878-1810","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"475429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoneyama, Misao"}],"nameIdentifiers":[{"nameIdentifier":"475430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirose, Jun"}],"nameIdentifiers":[{"nameIdentifier":"475431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minemoto, Yuzuru"}],"nameIdentifiers":[{"nameIdentifier":"475432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koyama, Takayoshi"}],"nameIdentifiers":[{"nameIdentifier":"475433","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kokuryo, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"475434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murayama, Shuhei"}],"nameIdentifiers":[{"nameIdentifier":"475435","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"475436","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tusneo"}],"nameIdentifiers":[{"nameIdentifier":"475437","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoshima, Sadahito"}],"nameIdentifiers":[{"nameIdentifier":"475438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"475439","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishizaka, Yukihito"}],"nameIdentifiers":[{"nameIdentifier":"475440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"米山 操","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"國領 大介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村山 周平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"バカロバ ルミアナ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475446","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Thermoactivatable Polymer-grafted Liposomes for Low-invasive Image-guided Chemotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thermoactivatable Polymer-grafted Liposomes for Low-invasive Image-guided Chemotherapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-10"},"publish_date":"2016-08-10","publish_status":"0","recid":"47459","relation_version_is_last":true,"title":["Thermoactivatable Polymer-grafted Liposomes for Low-invasive Image-guided Chemotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:39:35.701394+00:00"}