@article{oai:repo.qst.go.jp:00047459,
 author = {Aoki, Ichio and Yoneyama, Misao and Hirose, Jun and Minemoto, Yuzuru and Koyama, Takayoshi and Kokuryo, Daisuke and Murayama, Shuhei and Bakalova, Rumiana and Saga, Tusneo and Aoshima, Sadahito and Kono, Kenji and Ishizaka, Yukihito and 青木 伊知男 and 米山 操 and 國領 大介 and 村山 周平 and バカロバ ルミアナ and 佐賀 恒夫},
 issue = {6},
 journal = {Translational Research},
 month = {Aug},
 note = {The objective of this study was to develop a thermo-triggered, polymer-based liposomal drug carrier with an activatable MRI contrast property for monitoring the release of substances and for localized tumor therapy. The multimodal thermo-activatable polymer-grafted liposomes (MTPLs) was tested whether the accumulation of MTPLs in colon-26 grafted tumors could be visualized in vivo using MRI and optical imaging, whether MTPLs induce signal enhancement reflecting contents-release after triggering by tolerable short-term heating (42.5°C for 10 min) 8 h after MTPL administration (late-phase triggering), and whether MTPLs can provide a sufficient anti-tumor effect. The imaging and therapeutic properties of MTPLs were tested both in vitro and in vivo (BALB/c nude mice: heated group with MTPLs (n = 5), non-heated group with MTPLs (n = 5), heated group with doxorubicin-free MTPLs (n = 5), non-heated group with manganese-free MTPLs (n = 5), and kinetics observation group (n = 3); N = 23). Through in vivo MRI and fluorescent imaging, the MTPLs were shown to have significantly accumulated in the grafted colon-26 tumors 8 h after administration. Delayed thermo-triggering (9 h after administration) caused MR signal enhancement reflecting the contents-release upon short exposure to tolerable heat. In addition, significant anti-tumor effects were observed after treatment. The proposed polymer-based activatable MTPLs with a ‘delayed thermo-trigger’ provide a promising technology for cancer theranostics that allows for minimal side effects and rapid interactive therapy.},
 pages = {660--673},
 title = {Thermoactivatable Polymer-grafted Liposomes for Low-invasive Image-guided Chemotherapy},
 volume = {166},
 year = {2015}
}