WEKO3
アイテム
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Besides possible health effects resulting directly\nfrom radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showed\nthat chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibility\nof Trp53-heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and a\nsensational effect on the public, especially the residents living in radioactively contaminated areas. It is important to\ninvestigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type\n(Trp53wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS were\ninvestigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrow\nerythrocytes using a mouse restraint model. Five-week-old male Trp53wt C57BL/6J mice were restrained 6 h per day\nfor 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced a\nmarked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantly\nlower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS.\nCRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleated\nerythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in the\nincidences of micronucleated erythrocytes, regardless of CRIS. 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Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice
https://repo.qst.go.jp/records/47413
https://repo.qst.go.jp/records/47413ea75e82b-782b-4633-b0c6-fa730248ed67
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-05-18 | |||||
タイトル | ||||||
タイトル | Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
王, 冰
× 王, 冰× 田中, 薫× Katsube, Takanori× Ninomiya, Yasuharu× Vares, Guillaume× Liu, Qiang× Morita, Akinori× Nakajima, Tetsuo× Nenoi, Mitsuru× 王 冰× 田中 薫× 勝部 孝則× 二宮 康晴× Guillaume Vares× 中島 徹夫× 根井 充 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Both radiation and stresses cause detrimental effects on humans. Besides possible health effects resulting directly from radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showed that chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibility of Trp53-heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and a sensational effect on the public, especially the residents living in radioactively contaminated areas. It is important to investigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type (Trp53wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS were investigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrow erythrocytes using a mouse restraint model. Five-week-old male Trp53wt C57BL/6J mice were restrained 6 h per day for 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced a marked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantly lower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS. CRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleated erythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in the incidences of micronucleated erythrocytes, regardless of CRIS. These findings suggest that CRIS does not have a significant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53wt mice. |
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書誌情報 |
Journal of Radiation Research 巻 56, 号 5, p. 760-767, 発行日 2015-09 |
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出版者 | ||||||
出版者 | OXFORD | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | doi: 10.1093/jrr/rrv030 |