@article{oai:repo.qst.go.jp:00047413,
 author = {王, 冰 and 田中, 薫 and Katsube, Takanori and Ninomiya, Yasuharu and Vares, Guillaume and Liu, Qiang and Morita, Akinori and Nakajima, Tetsuo and Nenoi, Mitsuru and 王 冰 and 田中 薫 and 勝部 孝則 and 二宮 康晴 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 中島 徹夫 and 根井 充},
 issue = {5},
 journal = {Journal of Radiation Research},
 month = {Sep},
 note = {Both radiation and stresses cause detrimental effects on humans. Besides possible health effects resulting directly
from radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showed
that chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibility
of Trp53-heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and a
sensational effect on the public, especially the residents living in radioactively contaminated areas. It is important to
investigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type
(Trp53wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS were
investigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrow
erythrocytes using a mouse restraint model. Five-week-old male Trp53wt C57BL/6J mice were restrained 6 h per day
for 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced a
marked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantly
lower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS.
CRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleated
erythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in the
incidences of micronucleated erythrocytes, regardless of CRIS. These findings suggest that CRIS does not have a
significant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53wt mice.},
 pages = {760--767},
 title = {Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice},
 volume = {56},
 year = {2015}
}