{"created":"2023-05-15T14:36:47.986187+00:00","id":47413,"links":{},"metadata":{"_buckets":{"deposit":"dd0d5774-db11-496c-ba0b-922fc151ef4a"},"_deposit":{"created_by":1,"id":"47413","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47413"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047413","sets":["1"]},"author_link":["474749","474762","474758","474759","474754","474755","474761","474748","474752","474750","474757","474756","474753","474751","474747","474760"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"767","bibliographicPageStart":"760","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Both radiation and stresses cause detrimental effects on humans. Besides possible health effects resulting directly\nfrom radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showed\nthat chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibility\nof Trp53-heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and a\nsensational effect on the public, especially the residents living in radioactively contaminated areas. It is important to\ninvestigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type\n(Trp53wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS were\ninvestigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrow\nerythrocytes using a mouse restraint model. Five-week-old male Trp53wt C57BL/6J mice were restrained 6 h per day\nfor 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced a\nmarked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantly\nlower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS.\nCRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleated\nerythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in the\nincidences of micronucleated erythrocytes, regardless of CRIS. These findings suggest that CRIS does not have a\nsignificant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53wt mice.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"OXFORD"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"doi: 10.1093/jrr/rrv030","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"474747","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 薫"}],"nameIdentifiers":[{"nameIdentifier":"474748","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsube, Takanori"}],"nameIdentifiers":[{"nameIdentifier":"474749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ninomiya, Yasuharu"}],"nameIdentifiers":[{"nameIdentifier":"474750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Vares, Guillaume"}],"nameIdentifiers":[{"nameIdentifier":"474751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liu, Qiang"}],"nameIdentifiers":[{"nameIdentifier":"474752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morita, Akinori"}],"nameIdentifiers":[{"nameIdentifier":"474753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Tetsuo"}],"nameIdentifiers":[{"nameIdentifier":"474754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"474755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"勝部 孝則","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"二宮 康晴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474760","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 徹夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474762","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-18"},"publish_date":"2016-05-18","publish_status":"0","recid":"47413","relation_version_is_last":true,"title":["Chronic restraint-induced stress has little modifying effect on radiation hematopoietic toxicity in mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:40:09.155602+00:00"}