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Analysis of normal-appearing white matter of multiple sclerosis by tensor-based two-compartment model of water diffusion
https://repo.qst.go.jp/records/47392
https://repo.qst.go.jp/records/47392c5fb5482-d430-459b-a7ba-aa4ed4b704c6
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-01-28 | |||||
| タイトル | ||||||
| タイトル | Analysis of normal-appearing white matter of multiple sclerosis by tensor-based two-compartment model of water diffusion | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tachibana, Yasuhiko
× Tachibana, Yasuhiko× Obata, Takayuki× Inoue, Tomio× Aoki, Shigeki× al., et× 立花 泰彦× 小畠 隆行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: To compare the significance of the two-compartment model considering diffusional anisotropy with conventional diffusion analyzing methods regarding the detection of occult changes in normal-appearing white matter (NAWM) of multiple sclerosis (MS). Methods: Diffusion-weighted images (9 b-values with 6 directions) were acquired from twelve healthy female volunteers (22 - 52 years old, median 33 years) and 13 female MS patients (24 - 48 years old, median 37 years). Diffusion parameters based on the two-compartment model of water diffusion considering diffusional anisotropy was calculated by a proposed method. Other parameters including diffusion tensor imaging and conventional apparent diffusion coefficient (ADC) were also obtained. They were compared statistically between the control and MS groups. Results: Diffusion of the slow diffusion compartment in a radial direction of neuron fibers was elevated in MS patients (0.121 x10-3mm2/sec) in comparison to control (0.100 x10- 3mm2/sec), the difference being significant (P = 0.001). The difference between the groups was not significant in other comparisons including conventional ADC and fractional anisotropy (FA) of diffusion tensor imaging. Conclusion: The proposed method was applicable to clinically acceptable small data. The parameters obtained by this method improved the detectability of occult changes in NAWM compared to the conventional methods. |
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| 書誌情報 |
European Radiology 巻 25, 号 6, p. 1701-1707, 発行日 2015-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0938-7994 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 25577520 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s00330-014-3572-4 | |||||
