@article{oai:repo.qst.go.jp:00047392,
 author = {Tachibana, Yasuhiko and Obata, Takayuki and Inoue, Tomio and Aoki, Shigeki and al., et and 立花 泰彦 and 小畠 隆行},
 issue = {6},
 journal = {European Radiology},
 month = {Jan},
 note = {Objectives:
To compare the significance of the two-compartment model considering diffusional anisotropy with conventional diffusion analyzing methods regarding the detection of occult changes in normal-appearing white matter (NAWM) of multiple sclerosis (MS).
Methods:
Diffusion-weighted images (9 b-values with 6 directions) were acquired from twelve healthy female volunteers (22 - 52 years old, median 33 years) and 13 female MS patients (24 - 48 years old, median 37 years). Diffusion parameters based on the two-compartment model of water diffusion considering diffusional anisotropy was calculated by a proposed method. Other parameters including diffusion tensor imaging and conventional apparent diffusion coefficient (ADC) were also obtained. They were compared statistically between the control and MS groups.
Results:
Diffusion of the slow diffusion compartment in a radial direction of neuron fibers was elevated in MS patients (0.121 x10-3mm2/sec) in comparison to control (0.100 x10- 3mm2/sec), the difference being significant (P = 0.001). The difference between the groups was not significant in other comparisons including conventional ADC and fractional anisotropy (FA) of diffusion tensor imaging.
Conclusion:
The proposed method was applicable to clinically acceptable small data. The parameters obtained by this method improved the detectability of occult changes in NAWM compared to the conventional methods.},
 pages = {1701--1707},
 title = {Analysis of normal-appearing white matter of multiple sclerosis by tensor-based two-compartment model of water diffusion},
 volume = {25},
 year = {2015}
}