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Overexpression of NOTCH-regulated ankyrin repeat protein is associated with breast cancer cell proliferation
https://repo.qst.go.jp/records/47255
https://repo.qst.go.jp/records/472550e637fef-bc25-4445-b90b-0d8bdb139424
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-08-17 | |||||
| タイトル | ||||||
| タイトル | Overexpression of NOTCH-regulated ankyrin repeat protein is associated with breast cancer cell proliferation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Okutani, Tomomi× Kazuhiro, Daino× Iizuka, Daisuke× Nishimura, Mayumi× Shimada, Yoshiya× 今岡 達彦× 奥谷 倫未× 臺野 和広× 飯塚 大輔× 西村 まゆみ× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aim. NOTCH-regulated ankyrin repeat protein (NRARP) has been implicated in crosstalk between NOTCH and wingless-type mouse mammary tumor virus integration site (WNT) signals during development. Our study aimed to clarify its role in breast cancer cells. Materials and Methods. Public microarray data were used to analyse gene expression in human and rat breast cancer. A short interfering RNA was introduced into MCF7 and T47D human breast cancer cells for NRARP silencing. Gene expression was analysed by quantitative polymerase chain reaction. Results. The NRARP transcript was commonly overexpressed in various rat mammary cancer models. In addition, a subset of human breast cancer also expressed high levels of NRARP transcript, which correlated positively with up-regulation of cell proliferation-related genes. Silencing of NRARP suppressed the growth of MCF7 and T47D cells and lowered the expression of cell cycle-related genes in MCF7 cells. Conclusion. NRARP may stimulate cell proliferation in human breast cancer. | |||||
| 書誌情報 |
Anticancer Research 巻 34, 号 5, p. 2165-2171, 発行日 2014-05 |
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| 出版者 | ||||||
| 出版者 | International Institute of Anticancer Research (IIAR) | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0250-7005 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24778018 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://ar.iiarjournals.org/content/34/5/2165.long | |||||
| 関連名称 | http://ar.iiarjournals.org/content/34/5/2165.long | |||||
