{"created":"2023-05-15T14:36:41.005990+00:00","id":47255,"links":{},"metadata":{"_buckets":{"deposit":"94577b7b-2bf5-414b-a24f-2a120fcc53d9"},"_deposit":{"created_by":1,"id":"47255","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47255"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047255","sets":["1"]},"author_link":["472614","472612","472617","472620","472615","472609","472619","472610","472613","472611","472616","472618"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"2171","bibliographicPageStart":"2165","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Anticancer Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aim. NOTCH-regulated ankyrin repeat protein (NRARP) has been implicated in crosstalk between NOTCH and wingless-type mouse mammary tumor virus integration site (WNT) signals during development. Our study aimed to clarify its role in breast cancer cells. Materials and Methods. Public microarray data were used to analyse gene expression in human and rat breast cancer. A short interfering RNA was introduced into MCF7 and T47D human breast cancer cells for NRARP silencing. Gene expression was analysed by quantitative polymerase chain reaction. Results. The NRARP transcript was commonly overexpressed in various rat mammary cancer models. In addition, a subset of human breast cancer also expressed high levels of NRARP transcript, which correlated positively with up-regulation of cell proliferation-related genes. Silencing of NRARP suppressed the growth of MCF7 and T47D cells and lowered the expression of cell cycle-related genes in MCF7 cells. Conclusion. NRARP may stimulate cell proliferation in human breast cancer. ","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Institute of Anticancer Research (IIAR)"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24778018","subitem_relation_type_select":"PMID"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://ar.iiarjournals.org/content/34/5/2165.long"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ar.iiarjournals.org/content/34/5/2165.long","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0250-7005","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imaoka, Tatsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"472609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okutani, Tomomi"}],"nameIdentifiers":[{"nameIdentifier":"472610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazuhiro, Daino"}],"nameIdentifiers":[{"nameIdentifier":"472611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iizuka, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"472612","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"472613","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"472614","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今岡 達彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472615","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥谷 倫未","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"臺野 和広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"飯塚 大輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472620","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Overexpression of NOTCH-regulated ankyrin repeat protein is associated with breast cancer cell proliferation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Overexpression of NOTCH-regulated ankyrin repeat protein is associated with breast cancer cell proliferation"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-17"},"publish_date":"2015-08-17","publish_status":"0","recid":"47255","relation_version_is_last":true,"title":["Overexpression of NOTCH-regulated ankyrin repeat protein is associated with breast cancer cell proliferation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:42:02.170590+00:00"}