@article{oai:repo.qst.go.jp:00047255,
 author = {Imaoka, Tatsuhiko and Okutani, Tomomi and Kazuhiro, Daino and Iizuka, Daisuke and Nishimura, Mayumi and Shimada, Yoshiya and 今岡 達彦 and 奥谷 倫未 and 臺野 和広 and 飯塚 大輔 and 西村 まゆみ and 島田 義也},
 issue = {5},
 journal = {Anticancer Research},
 month = {May},
 note = {Background/Aim. NOTCH-regulated ankyrin repeat protein (NRARP) has been implicated in crosstalk between NOTCH and wingless-type mouse mammary tumor virus integration site (WNT) signals during development. Our study aimed to clarify its role in breast cancer cells. Materials and Methods. Public microarray data were used to analyse gene expression in human and rat breast cancer. A short interfering RNA was introduced into MCF7 and T47D human breast cancer cells for NRARP silencing. Gene expression was analysed by quantitative polymerase chain reaction. Results. The NRARP transcript was commonly overexpressed in various rat mammary cancer models. In addition, a subset of human breast cancer also expressed high levels of NRARP transcript, which correlated positively with up-regulation of cell proliferation-related genes. Silencing of NRARP suppressed the growth of MCF7 and T47D cells and lowered the expression of cell cycle-related genes in MCF7 cells. Conclusion. NRARP may stimulate cell proliferation in human breast cancer.},
 pages = {2165--2171},
 title = {Overexpression of NOTCH-regulated ankyrin repeat protein is associated with breast cancer cell proliferation},
 volume = {34},
 year = {2014}
}