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Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays.
https://repo.qst.go.jp/records/46996
https://repo.qst.go.jp/records/4699689d93038-032e-4e68-8d59-32782e63fae3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-12-16 | |||||
| タイトル | ||||||
| タイトル | Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takahashi, Momoko
× Takahashi, Momoko× Hirakawa, Hirokazu× Yajima, Hirohiko× Izumi-Nakajima, Nakako× Okayasu, Ryuichi× Fujimori, Akira× 平川 博一× 矢島 浩彦× 中島 菜花子× 岡安 隆一× 藤森 亮 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To obtain human glioblastoma cells A172 expressing stem cell-related protein and comparison of radiosensitivity in these cells with X-rays and carbon beam. Methods: Human monolayer-type A172 glioblastoma cells were maintained in normal medium with 10% bovine serum. In order to obtain sphere-type A172 cells the medium was replaced with serum-free medium supplemented with growth factors. Both types of A172 cells were irradiated with either X-rays or carbon ion beams and their radiosensitivity was evaluated. Results: Serum-free medium induced expression of stem cell-related proteins in A172 cells along with the neurosphere-like appearance. These sphere-type cells were found resistant to both X-rays and carbon ion beams. Phosphorylation of histone H2A family member X persisted for a longer period in the cells exposed to carbon ion beams than in those exposed to X-rays and it disappeared quicker in the sphere type than in the monolayer type. Relative radioresistance of the sphere type cells was smaller for carbon ion beams than for X-rays. Conclusions: We demonstrated that glioblastoma A172 cells with induced stem cell-related proteins turned resistant to irradiation. Accelerated heavy ion particles may have advantage over X-rays in overcoming the tumor resistance due to cell stemness. | |||||
| 書誌情報 |
International journal of radiation biology 巻 90, 号 12, p. 1125-1132, 発行日 2014-08 |
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| 出版者 | ||||||
| 出版者 | Informa Healthcare | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 24882391 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3109/09553002.2014.927933 | |||||
