{"created":"2023-05-15T14:36:29.588432+00:00","id":46996,"links":{},"metadata":{"_buckets":{"deposit":"9920473d-80dc-4401-b74d-bdaa82be8ede"},"_deposit":{"created_by":1,"id":"46996","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46996"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046996","sets":["1"]},"author_link":["469123","469116","469125","469118","469122","469119","469126","469124","469117","469121","469120"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1132","bibliographicPageStart":"1125","bibliographicVolumeNumber":"90","bibliographic_titles":[{"bibliographic_title":"International journal of radiation biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To obtain human glioblastoma cells A172 expressing stem cell-related protein and comparison of radiosensitivity in these cells with X-rays and carbon beam. Methods: Human monolayer-type A172 glioblastoma cells were maintained in normal medium with 10% bovine serum. In order to obtain sphere-type A172 cells the medium was replaced with serum-free medium supplemented with growth factors. Both types of A172 cells were irradiated with either X-rays or carbon ion beams and their radiosensitivity was evaluated. Results: Serum-free medium induced expression of stem cell-related proteins in A172 cells along with the neurosphere-like appearance. These sphere-type cells were found resistant to both X-rays and carbon ion beams. Phosphorylation of histone H2A family member X persisted for a longer period in the cells exposed to carbon ion beams than in those exposed to X-rays and it disappeared quicker in the sphere type than in the monolayer type. Relative radioresistance of the sphere type cells was smaller for carbon ion beams than for X-rays. Conclusions: We demonstrated that glioblastoma A172 cells with induced stem cell-related proteins turned resistant to irradiation. Accelerated heavy ion particles may have advantage over X-rays in overcoming the tumor resistance due to cell stemness.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Informa Healthcare"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24882391","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3109/09553002.2014.927933","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0955-3002","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takahashi, Momoko"}],"nameIdentifiers":[{"nameIdentifier":"469116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirakawa, Hirokazu"}],"nameIdentifiers":[{"nameIdentifier":"469117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yajima, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"469118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Izumi-Nakajima, Nakako"}],"nameIdentifiers":[{"nameIdentifier":"469119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okayasu, Ryuichi"}],"nameIdentifiers":[{"nameIdentifier":"469120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimori, Akira"}],"nameIdentifiers":[{"nameIdentifier":"469121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平川 博一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"矢島 浩彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中島 菜花子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森 亮","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469126","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-16"},"publish_date":"2014-12-16","publish_status":"0","recid":"46996","relation_version_is_last":true,"title":["Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:45:09.673068+00:00"}