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Influence of track directions on the biological consequences in cells irradiated with high LET heavy ions
https://repo.qst.go.jp/records/46714
https://repo.qst.go.jp/records/467143d230a49-fa62-4a21-9390-870137a8b956
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-02-06 | |||||
| タイトル | ||||||
| タイトル | Influence of track directions on the biological consequences in cells irradiated with high LET heavy ions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujii, Yoshihiro
× Fujii, Yoshihiro× Chuck, Yurkon× Maeda, Jyunko× Genet, Stefan× Okayasu, Ryuichi× Kitamura, Hisashi× Fujimori, Akira× Kato, Takamitsu× 藤井 義大× Ｃｈｕｃｋ Ｙｕｒｋｏｎ× Ｍａｅｄａ Ｊｙｕｎｋｏ× 岡安 隆一× 北村 尚× 藤森 亮× 加藤 宝光 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose : The impact of the damage distribution to cellular survival and chromosomal aberrations following high Linear Energy Transfer (LET) radiation was investigated. Materials and methods : High LET iron-ions (500 MeV/n, LET 200 keV/ um) were delivered to G1-phase synchronized Chinese Hamster Ovary (CHO) cells located at a vertical or horizontal angle relative to the ion beam in order to give same dose but diff erent fl uence and damage distribution. Results : Horizontal irradiation produced DNA double-strand break (DSB) along each ion track represented as clustered lines, and vertical irradiation produced a greater fl uence. The initial damages measured by premature chromosome condensation were equal per dose in both irradiation types. Horizontal irradiation proved to be less eff ective in cell killing than vertical at doses of more than 3 Gy. Vertical irradiation produced a higher number of metaphase chromosomal aberrations compared to horizontally irradiated samples. In particular, formation of exchange-type aberrations was the same, but that of deletiontype aberrations were signifi cantly higher after vertical irradiation than horizontal irradiation. Conclusions : Therefore, we concluded that high fl uence per dose is more eff ective than low fl uence per dose to produce radiationinduced chromosomal aberrations and to kill exposed cells following high LET heavy-ion exposure. |
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| 書誌情報 |
International Journal of Radiation Biology 巻 89, 号 6, p. 401-410, 発行日 2013-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
