@article{oai:repo.qst.go.jp:00046714,
 author = {Fujii, Yoshihiro and Chuck, Yurkon and Maeda, Jyunko and Genet, Stefan and Okayasu, Ryuichi and Kitamura, Hisashi and Fujimori, Akira and Kato, Takamitsu and 藤井 義大 and Ｃｈｕｃｋ Ｙｕｒｋｏｎ and Ｍａｅｄａ Ｊｙｕｎｋｏ and 岡安 隆一 and 北村 尚 and 藤森 亮 and 加藤 宝光},
 issue = {6},
 journal = {International Journal of Radiation Biology},
 month = {Jun},
 note = {Purpose : The impact of the damage distribution to cellular
survival and chromosomal aberrations following high Linear
Energy Transfer (LET) radiation was investigated.
Materials and methods : High LET iron-ions (500 MeV/n, LET
200 keV/ um) were delivered to G1-phase synchronized Chinese
Hamster Ovary (CHO) cells located at a vertical or horizontal
angle relative to the ion beam in order to give same dose but
diff erent fl uence and damage distribution.
Results : Horizontal irradiation produced DNA double-strand
break (DSB) along each ion track represented as clustered lines,
and vertical irradiation produced a greater fl uence. The initial
damages measured by premature chromosome condensation
were equal per dose in both irradiation types. Horizontal
irradiation proved to be less eff ective in cell killing than vertical
at doses of more than 3 Gy. Vertical irradiation produced a higher
number of metaphase chromosomal aberrations compared
to horizontally irradiated samples. In particular, formation of
exchange-type aberrations was the same, but that of deletiontype
aberrations were signifi cantly higher after vertical
irradiation than horizontal irradiation.
Conclusions : Therefore, we concluded that high fl uence per dose
is more eff ective than low fl uence per dose to produce radiationinduced
chromosomal aberrations and to kill exposed cells
following high LET heavy-ion exposure.},
 pages = {401--410},
 title = {Influence of track directions on the biological consequences in cells irradiated with high LET heavy ions},
 volume = {89},
 year = {2013}
}