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Radiation-Sensitising Effects of Antennapedia Proteins (ANTP)-SmacN7 on Tumour Cells
https://repo.qst.go.jp/records/46694
https://repo.qst.go.jp/records/466941a40cccf-89a4-4143-ac99-a8b843ad3d60
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-01-14 | |||||
| タイトル | ||||||
| タイトル | Radiation-Sensitising Effects of Antennapedia Proteins (ANTP)-SmacN7 on Tumour Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Li, Qing Du(杜 利清)
× Li, Qing Du(杜 利清)× Yan, Wang(王 彦)× Chang, Xu(徐 暢)× Jia, Cao (曹 佳)× Qin, Wang (王 勤)× Hui, Zhao(趙 輝)× Fei-Yue, Fan(樊 飛躍)× 王, 冰× 勝部, 孝則× Sai, Jun Fan(樊 賽軍)× Qiang, Liu(劉 強)× 王 冰× 勝部 孝則 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | he objective of this study was to investigate the underlying mechanisms behind the radiation-sensitising effects of the antennapedia proteins (ANTP)-smacN7 fusion protein on tumour cells. ANTP-SmacN7 fusion proteins were synthesised, and the ability of this fusion protein to penetrate cells was observed. Effects of radiation on the expression of X-linked inhibitor of apoptosis protein (XIAP) were detected by western blotting. The radiation-sensitising effects of ANTP-SmacN7 fusion proteins were observed by a clonogenic assay. The effects of drugs and radiation on tumour cell apoptosis were determined using Annexin V/FITC double staining. Changes in caspase-8, caspase-9 and caspase-3 were detected by western blot before and after ANTP-SmacN7 inhibition of XIAP. The ANTP-SmacN7 fusion protein could enter and accumulate in cells; in vitro XIAP expression of radiation-induced tumour cells was negatively correlated with tumor radiosensitivity. The ANTP-SmacN7 fusion protein promoted tumour cell apoptosis through the activation of caspase3. ANTP-SmacN7 fusion protein may reduce tumour cell radioresistance by inducing caspase3 activation. | |||||
| 書誌情報 |
International Journal of Molecular Sciences. 巻 14, 号 12, p. 24087-24096, 発行日 2013-12 |
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| 出版者 | ||||||
| 出版者 | Multidisciplinary Digital Publishing Institute | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | doi:10.3390/ijms141224087 | |||||
