{"created":"2023-05-15T14:36:16.341633+00:00","id":46694,"links":{},"metadata":{"_buckets":{"deposit":"6b0c29f9-2c4d-45ef-a337-7f1f6a47d38f"},"_deposit":{"created_by":1,"id":"46694","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46694"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046694","sets":["1"]},"author_link":["465592","465586","465590","465588","465581","465582","465585","465591","465587","465593","465589","465584","465583"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"24096","bibliographicPageStart":"24087","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences."}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"he objective of this study was to investigate the underlying mechanisms behind the radiation-sensitising effects of the antennapedia proteins (ANTP)-smacN7 fusion protein on tumour cells. ANTP-SmacN7 fusion proteins were synthesised, and the ability of this fusion protein to penetrate cells was observed. Effects of radiation on the expression of X-linked inhibitor of apoptosis protein (XIAP) were detected by western blotting. The radiation-sensitising effects of ANTP-SmacN7 fusion proteins were observed by a clonogenic assay. The effects of drugs and radiation on tumour cell apoptosis were determined using Annexin V/FITC double staining. Changes in caspase-8, caspase-9 and caspase-3 were detected by western blot before and after ANTP-SmacN7 inhibition of XIAP. The ANTP-SmacN7 fusion protein could enter and accumulate in cells; in vitro XIAP expression of radiation-induced tumour cells was negatively correlated with tumor radiosensitivity. The ANTP-SmacN7 fusion protein promoted tumour cell apoptosis through the activation of caspase3. ANTP-SmacN7 fusion protein may reduce tumour cell radioresistance by inducing caspase3 activation.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Multidisciplinary Digital Publishing Institute "}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"doi:10.3390/ijms141224087","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Li, Qing Du(杜 利清)"}],"nameIdentifiers":[{"nameIdentifier":"465581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yan, Wang(王 彦)"}],"nameIdentifiers":[{"nameIdentifier":"465582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chang, Xu(徐 暢)"}],"nameIdentifiers":[{"nameIdentifier":"465583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jia, Cao (曹 佳)"}],"nameIdentifiers":[{"nameIdentifier":"465584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Qin, Wang (王 勤)"}],"nameIdentifiers":[{"nameIdentifier":"465585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hui, Zhao(趙 輝)"}],"nameIdentifiers":[{"nameIdentifier":"465586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fei-Yue, Fan(樊 飛躍)"}],"nameIdentifiers":[{"nameIdentifier":"465587","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"465588","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"勝部, 孝則"}],"nameIdentifiers":[{"nameIdentifier":"465589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sai, Jun Fan(樊 賽軍)"}],"nameIdentifiers":[{"nameIdentifier":"465590","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Qiang, Liu(劉 強)"}],"nameIdentifiers":[{"nameIdentifier":"465591","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465592","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"勝部 孝則","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"465593","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Radiation-Sensitising Effects of Antennapedia Proteins (ANTP)-SmacN7 on Tumour Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radiation-Sensitising Effects of Antennapedia Proteins (ANTP)-SmacN7 on Tumour Cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-01-14"},"publish_date":"2014-01-14","publish_status":"0","recid":"46694","relation_version_is_last":true,"title":["Radiation-Sensitising Effects of Antennapedia Proteins (ANTP)-SmacN7 on Tumour Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:48:44.747837+00:00"}