@article{oai:repo.qst.go.jp:00046694,
 author = {Li, Qing Du(杜 利清) and Yan, Wang(王 彦) and Chang, Xu(徐 暢) and Jia, Cao (曹 佳) and Qin, Wang (王 勤) and Hui, Zhao(趙 輝) and Fei-Yue, Fan(樊 飛躍) and 王, 冰 and 勝部, 孝則 and Sai, Jun Fan(樊 賽軍) and Qiang, Liu(劉 強) and 王 冰 and 勝部 孝則},
 issue = {12},
 journal = {International Journal of Molecular Sciences.},
 month = {Dec},
 note = {he objective of this study was to investigate the underlying mechanisms behind the radiation-sensitising effects of the antennapedia proteins (ANTP)-smacN7 fusion protein on tumour cells. ANTP-SmacN7 fusion proteins were synthesised, and the ability of this fusion protein to penetrate cells was observed. Effects of radiation on the expression of X-linked inhibitor of apoptosis protein (XIAP) were detected by western blotting. The radiation-sensitising effects of ANTP-SmacN7 fusion proteins were observed by a clonogenic assay. The effects of drugs and radiation on tumour cell apoptosis were determined using Annexin V/FITC double staining. Changes in caspase-8, caspase-9 and caspase-3 were detected by western blot before and after ANTP-SmacN7 inhibition of XIAP. The ANTP-SmacN7 fusion protein could enter and accumulate in cells; in vitro XIAP expression of radiation-induced tumour cells was negatively correlated with tumor radiosensitivity. The ANTP-SmacN7 fusion protein promoted tumour cell apoptosis through the activation of caspase3. ANTP-SmacN7 fusion protein may reduce tumour cell radioresistance by inducing caspase3 activation.},
 pages = {24087--24096},
 title = {Radiation-Sensitising Effects of Antennapedia Proteins (ANTP)-SmacN7 on Tumour Cells},
 volume = {14},
 year = {2013}
}