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Aconitum C20_Diterpenoid alkaloid derivatives regulate the growth and differentiation of cord blood derived human hematopoietic stem/progenitor cells.
https://repo.qst.go.jp/records/46639
https://repo.qst.go.jp/records/46639afc03ef1-d47e-4843-88b7-938f94cfecb3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-11-26 | |||||
| タイトル | ||||||
| タイトル | Aconitum C20_Diterpenoid alkaloid derivatives regulate the growth and differentiation of cord blood derived human hematopoietic stem/progenitor cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hazawa, Masaharu
× Hazawa, Masaharu× Wada, Koji× Kashiwakura, Ikuo× 羽澤 勝治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The pharmacological activity of Aconitum alkaloids depends on their fundamental structure. While C₁₉-norditerpenoid alkaloids present significant toxicity to the central nervous system, C₂₀-diterpenoid alkaloids have reduced toxicities. However, there is little information regarding the precise pharmacological properties of C₂₀-diterpenoid alkaloids. C₂₀-diterpenoid alkaloid derivatives have explicit structure-activity relationships targeting various tumor cells, which depend on the C11-substrate. However, the present study showed that C6-derivatives additively or synergistically sustained proliferation of CD34⁺ hematopoietic stem/progenitor cells derived from the placental/umbilical cord blood. It revealed that identical structures belonging to C₂₀-diterpenoid alkaloids surprisingly have opposing proliferative effects depending on the derivatization sites (C6 versus C11). | |||||
| 書誌情報 |
Phytotherapy Research 巻 26, 号 8, p. 1262-4, 発行日 2012-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0951-418X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/ptr.3718 | |||||
