@article{oai:repo.qst.go.jp:00046639,
 author = {Hazawa, Masaharu and Wada, Koji and Kashiwakura, Ikuo and 羽澤 勝治},
 issue = {8},
 journal = {Phytotherapy Research},
 month = {Jan},
 note = {The pharmacological activity of Aconitum alkaloids depends on their fundamental structure. While C₁₉-norditerpenoid alkaloids present significant toxicity to the central nervous system, C₂₀-diterpenoid alkaloids have reduced toxicities. However, there is little information regarding the precise pharmacological properties of C₂₀-diterpenoid alkaloids. C₂₀-diterpenoid alkaloid derivatives have explicit structure-activity relationships targeting various tumor cells, which depend on the C11-substrate. However, the present study showed that C6-derivatives additively or synergistically sustained proliferation of CD34⁺ hematopoietic stem/progenitor cells derived from the placental/umbilical cord blood. It revealed that identical structures belonging to C₂₀-diterpenoid alkaloids surprisingly have opposing proliferative effects depending on the derivatization sites (C6 versus C11).},
 pages = {1262--4},
 title = {Aconitum C20_Diterpenoid alkaloid derivatives regulate the growth and differentiation of cord blood derived human hematopoietic stem/progenitor cells.},
 volume = {26},
 year = {2012}
}