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Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging
https://repo.qst.go.jp/records/46522
https://repo.qst.go.jp/records/46522d3fec747-5a73-4b26-bd86-b252d390d124
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-04-11 | |||||
| タイトル | ||||||
| タイトル | Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Mi, Peng
× Mi, Peng× Cabral, Horacio× Kokuryo, Daisuke× Aoki, Ichio× Saga, Tsuneo× Kataoka, Kazunori× Nishiyama, Nobuhiro× et.al× 國領 大介× 青木 伊知男× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nanodevices for magnetic resonance imaging of cancer were self-assembled to coreeshell micellarstructures by metal complex formation of K2PtCl6 withdiethylenetriaminepentaacetic acid gadolinium (III) dihydrogen (Gd-DTPA), a T1-contrast agent, and poly(ethylene glycol)-b-poly{N-[N0-(2-aminoethyl)- 2-aminoethyl]aspartamide} (PEG-b-PAsp(DET)) copolymer in aqueous solution. Gd-DTPAloaded polymeric micelles (Gd-DTPA/m) showed a hydrodynamic diameter of 45 nm and a core size of 22 nm. Con!ning Gd-DTPA inside the core of the micelles increased the relaxivity of Gd-DTPA more than 13 times (48 mM!1 s!1). In physiological conditions Gd-DTPA/m sustainedly released Gd-DTPA, while the Pt(IV) complexes remain bound to the polymer. Gd-DTPA/m extended the circulation time in plasma and augmented the tumor accumulation of Gd-DTPA leading to successful contrast enhancement of solid tumors. m-Synchrotron radiation-X-ray "uorescence results con!rmed that Gd-DTPA was delivered to the tumor site by the micelles. Our study provides a facile strategy for incorporating contrast agents, dyes and bioactive molecules into nanodevices for developing safe and ef!cient drug carriers for clinical application. |
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| 書誌情報 |
Biomaterials 巻 34, 号 2, p. 492-500, 発行日 2012-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0142-9612 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | www.elsevier.com/locate/biomaterials | |||||
| 関連名称 | www.elsevier.com/locate/biomaterials | |||||
