@article{oai:repo.qst.go.jp:00046522,
 author = {Mi, Peng and Cabral, Horacio and Kokuryo, Daisuke and Aoki, Ichio and Saga, Tsuneo and Kataoka, Kazunori and Nishiyama, Nobuhiro and et.al and 國領 大介 and 青木 伊知男 and 佐賀 恒夫},
 issue = {2},
 journal = {Biomaterials},
 month = {Sep},
 note = {Nanodevices for magnetic resonance imaging of cancer were self-assembled to coreeshell micellarstructures by metal complex formation of K2PtCl6 withdiethylenetriaminepentaacetic acid gadolinium (III) dihydrogen (Gd-DTPA), a T1-contrast agent, and poly(ethylene glycol)-b-poly{N-[N0-(2-aminoethyl)-
2-aminoethyl]aspartamide} (PEG-b-PAsp(DET)) copolymer in aqueous solution. Gd-DTPAloaded polymeric micelles (Gd-DTPA/m) showed a hydrodynamic diameter of 45 nm and a core size of 22 nm. Con!ning Gd-DTPA inside the core of the micelles increased the relaxivity of Gd-DTPA more than 13 times (48 mM!1 s!1). In physiological conditions Gd-DTPA/m sustainedly released Gd-DTPA, while the Pt(IV) complexes remain bound to the polymer. Gd-DTPA/m extended the circulation time in plasma and augmented the tumor accumulation of Gd-DTPA leading to successful contrast enhancement of solid tumors. m-Synchrotron radiation-X-ray "uorescence results con!rmed that Gd-DTPA was delivered to the tumor site by the micelles. Our study provides a facile strategy for incorporating contrast agents, dyes and bioactive molecules into nanodevices for developing safe and ef!cient drug carriers for clinical application.},
 pages = {492--500},
 title = {Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging},
 volume = {34},
 year = {2012}
}