{"created":"2023-05-15T14:36:08.484453+00:00","id":46522,"links":{},"metadata":{"_buckets":{"deposit":"8b0ac12e-8ce3-4fb6-9da2-6fe0974bcc77"},"_deposit":{"created_by":1,"id":"46522","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46522"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046522","sets":["1"]},"author_link":["463610","463607","463611","463609","463612","463605","463602","463603","463606","463608","463604"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"500","bibliographicPageStart":"492","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Biomaterials"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Nanodevices for magnetic resonance imaging of cancer were self-assembled to coreeshell micellarstructures by metal complex formation of K2PtCl6 withdiethylenetriaminepentaacetic acid gadolinium (III) dihydrogen (Gd-DTPA), a T1-contrast agent, and poly(ethylene glycol)-b-poly{N-[N0-(2-aminoethyl)-\n2-aminoethyl]aspartamide} (PEG-b-PAsp(DET)) copolymer in aqueous solution. Gd-DTPAloaded polymeric micelles (Gd-DTPA/m) showed a hydrodynamic diameter of 45 nm and a core size of 22 nm. Con!ning Gd-DTPA inside the core of the micelles increased the relaxivity of Gd-DTPA more than 13 times (48 mM!1 s!1). In physiological conditions Gd-DTPA/m sustainedly released Gd-DTPA, while the Pt(IV) complexes remain bound to the polymer. Gd-DTPA/m extended the circulation time in plasma and augmented the tumor accumulation of Gd-DTPA leading to successful contrast enhancement of solid tumors. m-Synchrotron radiation-X-ray \"uorescence results con!rmed that Gd-DTPA was delivered to the tumor site by the micelles. Our study provides a facile strategy for incorporating contrast agents, dyes and bioactive molecules into nanodevices for developing safe and ef!cient drug carriers for clinical application.","subitem_description_type":"Abstract"}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"www.elsevier.com/locate/biomaterials"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"www.elsevier.com/locate/biomaterials","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0142-9612","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mi, Peng"}],"nameIdentifiers":[{"nameIdentifier":"463602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Cabral, Horacio"}],"nameIdentifiers":[{"nameIdentifier":"463603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kokuryo, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"463604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"463605","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"463606","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kataoka, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"463607","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishiyama, Nobuhiro"}],"nameIdentifiers":[{"nameIdentifier":"463608","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"463609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"國領 大介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463610","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463611","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463612","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-04-11"},"publish_date":"2013-04-11","publish_status":"0","recid":"46522","relation_version_is_last":true,"title":["Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:50:46.122496+00:00"}