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A New Mutation of Mouse Ruby-eye 2, ru2d/Hps5ru2-d Inhibits Eumelanin Synthesis but Stimulates Pheomelanin Synthesis in Melanocytes
https://repo.qst.go.jp/records/46424
https://repo.qst.go.jp/records/46424c2d909a8-b131-455d-b5a6-ad082a7ed5af
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-10-12 | |||||
| タイトル | ||||||
| タイトル | A New Mutation of Mouse Ruby-eye 2, ru2d/Hps5ru2-d Inhibits Eumelanin Synthesis but Stimulates Pheomelanin Synthesis in Melanocytes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Wakamatsu, Kazumasa× Ito, Shosuke× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We previously demonstrated that a novel mutation, characterized by light-colored coats and ruby eyes, which occurred spontaneously in mice in our laboratory, exhibited deletion in the Hps5 gene (ru2d/Hps5ru2-d). To clarify the mechanism of this hypopigmentation, the characteristics of the neonatal development of ru2d/ru2d melanocytes were investigated in detail with special reference to those of +/+ melanocytes. In ru2d/ru2d mice, there were fewer epidermal melanocytes than in +/+ mice, whereas there was no difference in the numbers of epidermal melanoblasts in +/+ and ru2d/ru2d mice, both in dorsal and ventral skins. Epidermal melanocytes with increased dopa-melanin deposition and dendritogenesis were greatly increased by injecting L-Tyr subcutaneously into newborn ru2d/ru2d mice. The eumelanin content in the epidermis and dermis in postnatal ru2d/ru2d mice was much lower than in +/+ mice, whereas similar pheomelanin content was observed 5.5 or 7.5 days after birth both in dorsal and ventral skins. Moreover, the eumelanin content in the dorsal and ventral hairs in 5-week-old ru2d/ru2d mice was much lower than in +/+ mice, whereas pheomelanin content were two to four times greater than in +/+ mice. These results suggest that the ru2d allele suppresses the differentiation of melanocytes through the inhibition of eumelanin synthesis, but stimulates pheomelanin synthesis in melanocytes. | |||||
| 書誌情報 |
Zoological Science 巻 29, 号 10, p. 652-661, 発行日 2012-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0289-0003 | |||||
